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Human Vitronectin, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human Vitronectin, Tag Free at 2 ug/mL (100 uL/well) can bind Human ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free with a linear range of 0.078-1.25 ug/mL (QC tested).
Human Vitronectin, Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Vitronectin / VTN Recombinant Protein

CATALOG NUMBER: 11-248

Tested Applications:
ELISA, WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Asp 20 -Arg 398
Fusion Tag:
Tag Free
Tested Applications:
ELISA, WB
Application Note:
This protein carries no "tag". The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE).
Predicted Molecular Weight:
43.2 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
20 mM Tris-HCl, Arginine, pH8.0
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
VTN
Additional Names:
VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor
Protein Accession Number:
NP_000629.3
Ncbi Gene Id Number:
7448
Background:
Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Background Reference 1:
Kohler S, et al. 2015 Thromb Haemost. 113:125-42. (2) Salazar-Peláez LM, et al. 2015. PLoS One. 10(3):e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14(5):600-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-248

List Size:
0.1 mg

List Price:

$275.00

Out of stock

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