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Human VSIG3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human VSIG3, Fc Tag at 5 ug/mL (100 uL/well) can bind Human B7-H5, Mouse IgG2a Fc Tag, low endotoxin with a linear range of 0.313-10 ug/mL (Routinely tested).
Human VSIG3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

VSIG3 Recombinant Protein

CATALOG NUMBER: 11-339

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Leu 23 - Gly 241
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
49.7 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
Tris with Glycine, Arginine and NaCl, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
IGSF11
Additional Names:
VSIG3,IgSF11,CXADRL1,Bt-IgSF,CT119
Protein Accession Number:
NP_001015887.1
Ncbi Gene Id Number:
152404
Background:
VSIG3, also known as IGSF11, BT-IgSF, and CLMP, is a homophilic adhesion molecule that preferentially expressed in the brain. The function of VSIG3 is to stimulate cell growth through homophilic interactions. In clinical, the VSIG3 has been reported to as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also a ligand of B7 family member VISTA/PD-1H and inhibits human T-cell functions through a novel VSIG-3/VISTA pathway. VSIG-3/VISTA co-inhibitory pathway may provide new strategies for the treatment of human cancers and autoimmune disorders.
Background Reference 1:
Jang S, et al. 2016. Nat Neurosci. 19:84-93.
Background Reference 2:
Watanabe T, et al. 2005. Cancer Science. 96(8):498-506.
Background Reference 3:
Wang J, et al. 2019. Immunology. 156(1):74-81.
Background Reference 4:
Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-339

List Size:
0.1 mg

List Price:

$577.00

Datasheet
Shipping Info

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