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Human B7-H4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human B7-H4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

VTCN1 Recombinant Protein

CATALOG NUMBER: 96-049

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Phe 29 - Ala 258
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
26.4 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H4, His Tag at 2 ug/mL can bind anti-B7-H4 mAb (Human IgG1) with a linear range of 0.4-6 ng/mL.
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH 7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
VTCN1
Additional Names:
B7-H4, VTCN1, B7S1, B7h.5
Protein Accession Number:
NP_078902
Ncbi Gene Id Number:
79679
Background:
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Background Reference 1:
Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
Background Reference 2:
Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
Background Reference 3:
Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-049

List Size:
0.1 mg

List Price:

$463.00

Datasheet
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