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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

WNT3 Antibody

CATALOG NUMBER: 57-501

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Xenopus
Immunogen:
This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 amino acids from the Central region of human WNT3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
40 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
WNT3
Additional Names:
Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4
Protein Accession Number:
P56703
Protein Gi Number:
14424477
Ncbi Gene Id Number:
7473
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast,rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.
Background Reference 1:
Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88(9):748-756(2010)
Background Reference 2:
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Background Reference 3:
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Background Reference 4:
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-501

List Size:
400 ul

List Price:

$495.00

Datasheet
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