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Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HepG2 cells treated with Anisomycin using Phospho-XIAP (Ser87) Antibody. The lane on the right is treated with the antigen-specific peptide.

XIAP (phospho Ser87) Antibody

CATALOG NUMBER: 80-006

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
XIAP (phospho Ser87) antibody was raised against a peptide sequence around phosphorylation site of serine87 (K-V-S (p)-P-N) derived from Human XIAP .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of XIAP only when phosphorylated at serine 87.
Predicted Molecular Weight:
57 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
XIAP
Additional Names:
API3, BIR4, BIRC4, IAP3, X-linked IAP
Protein Accession Number:
NP_001158.2
Protein Gi Number:
32528299
Ncbi Gene Id Number:
331
Background:
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.
Background Reference 1:
Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

80-006

List Size:
0.1 mg

List Price:

$355.00

Out of stock

Datasheet
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