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Western blot analysis of ZNF346 in human kidney tissue lysate with ZNF346 antibody (A) 0.5 and (B) 1 μg/mL.
Western blot analysis of ZNF346 in human kidney tissue lysate with ZNF346 antibody (A) 0.5 and (B) 1 μg/mL.
Trial Size

ZNF346 Antibody

CATALOG NUMBER: 6003

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
ZNF346 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of human ZNF346.
The immunogen is located within amino acids 70 - 120 of ZNF346.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1305 - Human Kidney Tissue Lysate
Purification:
ZNF346 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
ZNF346 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
ZNF346 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ZNF346
Additional Names:
ZNF346 Antibody: JAZ, Zfp346, JAZ, Zinc finger protein 346, Just another zinc finger protein
Protein Accession Number:
NP_036411
Protein Gi Number:
6912440
Ncbi Gene Id Number:
23567
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ZNF346 Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
Background Reference 1:
Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn.1993; 11:557-70.
Background Reference 2:
Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep.2000; 1:287-92.
Background Reference 3:
Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem.1999; 274: 27399-406.
Background Reference 4:
Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol.2004; 24:6608-19.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6003

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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