CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.
ProSci’s monoclonal immune checkpoint antibodies made to improve in vitro studies. Unlike antibodies developed using proteins made in yeast or bacteria, these B7-H3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. They are guaranteed to work for their tested applications.
Sets consist of 20µg aliquots of several mouse monoclonal antibodies with different binding features allowing for selection of the best clone for your application.
ProSci’s Risk-Free B7-H3 antibodies are rigorously tested and guaranteed to work for their designated applications. Mouse monoclonal B7-H3 antibodies were raised against the extracellular domain of human B7-H3.
KEY:
| Cat. No. | Product Type | Source |
|---|---|---|
| RF16090-01 | Recombinant Protein | HEK293 |
| RF10001-02 | Negative Control (Cell Lysate) | HEK293 |
| RF10002-05 | Positive Control (Tissue Slides) | Human Spleen |
| Cat. No. | Name | Host | Clonality | Applications |
|---|---|---|---|---|
| 8689 | CD276 Antibody | Rabbit | Polyclonal | ELISA, IF, IHC-P, WB |
For additional information on B7-H3 (CD276), visit
