The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).
ProSci’s monoclonal immune checkpoint antibodies made to improve in vitro studies. Unlike antibodies developed using proteins made in yeast or bacteria, these LAG-3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. They are guaranteed to work for their tested applications.
Sets consist of 20µg aliquots of several mouse monoclonal antibodies with different binding features allowing for selection of the best clone for your application.
ProSci’s Risk-Free LAG-3 antibodies are rigorously tested and guaranteed to work for their designated applications. Mouse monoclonal LAG-3 antibodies were raised against the extracellular domain of human LAG-3.
KEY:
Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications.
Sets consist of 20µg aliquots of several single domain antibodies with different binding features allowing for selection of the best clone for your application.
| Product Set | Contents |
|---|---|
| Single Domain LAG-3 Set (SD8700) | SD8837, SD8839, SD8841, SD8842 |
KEY:
| Cat. No. | Product Type | Source |
|---|---|---|
| RF16080-01 | Recombinant Protein | HEK293 |
| RF10001-03 | Positive Control (Tissue Lysate) | Human Spleen |
| RF10001-02 | Negative Control (Cell Lysate) | HEK293 |
| RF10002-03 | Positive Control (Tissue Slides) | Human Spleen |
| RF10002-02 | Negative Control (Cell Slides) | HEK293 |
| Cat. No. | Name | Host | Clonality | Applications |
|---|---|---|---|---|
| 8655 | LAG-3 Antibody | Rabbit | Polyclonal | ELISA, IF, IHC-P, WB |
For additional information on LAG-3, visit
