To support the efforts of researchers worldwide in understanding and combating the COVID-19 virus (SARS-CoV-2) and other coronaviruses, ProSci Incorporated provides validated coronavirus receptor ACE2 antibodies, as well as related targets. Check out our ACE2 Antibody (Cat. No. 3217) that was cited in Cell.
Angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney, and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus SARS-CoV-2. Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role in both cross-species and human-to-human transmissions of SARS-CoV-2.
ACE2 interacts with the spike protein (S) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2. The SARS-COV-2 spike protein receptor-binding domain structure is similar to the SARS spike protein suggesting a similar function. In a study on SARS-CoV, the virus infection occurred in well-differentiated ciliated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.
ProSci offers antibodies and recombinant proteins for ACE2:
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| ACE2 Antibody | 3215 | ELISA, IF, IHC-P, WB | Polyclonal |
| ACE2 Antibody | 3217 | ELISA, IF, IHC-P, WB | Polyclonal |
| ACE2 Antibody (biotin) | 3217-biotin | ELISA | Polyclonal |
| ACE2 Antibody (HRP) | 3217-HRP | ELISA | Polyclonal |
| ACE2 Antibody | 3227 | ELISA, IF, IHC-P, WB | Polyclonal |
| ACE2 Antibody | 3229 | ELISA, IF, IHC-P, WB | Polyclonal |
| ACE2 Antibody | 24-033 | WB, IHC | Polyclonal |
| ACE2 Antibody [3F1] | 10-604 | WB, IF, IHC | Monoclonal |
| ACE2 Antibody[AC18F] | 36-031 | ELISA, Flow, WB | Monoclonal |
| ACE2 Antibody[AC18F](biotin) | 36-032 | ELISA, Flow, WB | Monoclonal |
| ACE2 Antibody [AC384] | 36-038 | ELISA, WB | Monoclonal |
| ACE2 Antibody [AC384] (biotin) | 36-039 | ELISA, WB | Monoclonal |
| Product | Cat. No. | Source | Fusion Tag | Sequence |
|---|---|---|---|---|
| Human ACE2 Recombinant Protein | 10-421 | Mammalian Cells | C-His Tag | Ser19 - Asp615 |
| Human ACE2 Recombinant Protein | 10-430 | E. Coli | N-His Tag | Leu392 - Ser740 |
| Human ACE2 Recombinant Protein | 10-432 | Mammalian Cells | Tag Free | Met1 - Ser740 |
| Human ACE2 Recombinant Protein | 10-114 | Human Cells | C-His-Avi Tag | Gln18 - Ser740 |
| Human ACE2 Recombinant Protein | 10-120 | Human Cells | C-Fc Tag | Gln18 - Ser740 |
| Biotinylated Human ACE2 Recombinant Protein | 10-202 | HEK293 Cells | His-Avi Tag | Gln18 - Ser740 |
| ACE2 Recombinant Protein | 92-724 | Human Cells | C-10 His Tag | Gln18 - Thr740 |
| Rhesus Macaque ACE2 Recombinant Protein | 92-725 | Human Cells | C-10 His Tag | Gln18 - Val739 |
| Rhesus Macaque ACE2 Recombinant Protein | 92-726 | Human Cells | C-Fc Tag | Gln18 - Val739 |
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| TMPRRS2 Antibody | 24-034 | IHC, WB | Monoclonal |
| TMPRRS2 Antibody | 46-908 | ELISA, WB | Polyclonal |
| TMPRRS2 Antibody | 18-426 | IHC, WB | Polyclonal |
| TMPRRS2 Antibody | 62-863 | Flow, WB | Polyclonal |
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| Furin Antibody | 22-945 | IHC, WB | Polyclonal |
| Furin Antibody | 14-925 | WB | Polyclonal |
| Furin Antibody | 43-351 | ELISA, WB | Polyclonal |
| Product | Cat. No. | Source | Fusion Tag | Sequence |
|---|---|---|---|---|
| Furin Recombinant Protein | 40-542 | HEK cells | His | Asp108-Glu715 |
