SARS-CoV-2 Small Molecule Inhibitors

Viral Entry

ProductCat. No.TargetAntiviral Activity
Amastatin . hydrochloride10-016Viral entry ANPEP (Aminopeptidase N)Viral Replication
Camostat . mesylate10-017Viral entry TMPRSS2Viral Replication
Nafamostat . mesylate10-031Viral entry TMPRSS2Viral Replication
Umifenovir . HCl [Arbidol]10-048Viral entry Fusion into host cellsViral Replication

Lysosome/Endosome

ProductCat. No.TargetAntiviral Activity
Chloroquine . diphosphate10-018Lysosome function Zinc ionophoreViral Replication
Hydroxychloroquine . sulfate10-019Lysosome function Zinc ionophoreViral Replication
Niclosamide10-033Endosome acidificationViral Replication
Niclosamide . ethanolamine10-034Endosome acidificationViral Replication

Viral Protease

ProductCat. No.TargetAntiviral Activity
Darunavir10-021Papain-like viral protease (PLVP)Viral Maturation/Replication
Darunavir . ethanolate10-022Papain-like viral protease (PLVP)Viral Maturation/Replication
Famotidine10-026SARS-CoV-2 papain-like protease (PLpro)Viral Replication
Mycophenolic acid10-030SARS-CoV-2 papain-like protease (PLpro)Viral Replication
Ebselen10-023Main Protease (Mpro)/3C-like ProteaseViral Transcription/Replication
Shikonin10-045Main Protease (Mpro)/3C-like ProteaseViral Transcription/Replication
Rosuvastatin . calcium salt10-041Main Protease MproViral Replication
Saquinavir . mesylate10-044Main Protease MproViral Replication

Viral RNA-dependent RNA polymerase (RdRps)

ProductCat. No.TargetAntiviral Activity
Remdesivir10-037RNA-dependent RNA polymerases (RdRps)Viral Transcription/Replication
Remdesivir Metabolite (GS-441524)10-038RNA-dependent RNA polymerases (RdRps)Viral Transcription/Replication
EIDD-280110-024RNA-dependent RNA polymerases (RdRps)Viral Transcription/Replication
Favipiravir10-027RNA-dependent RNA polymerases (RdRps)Viral Transcription/Replication
Elbasvir10-025RdRP, Papain-like Proteinase and HelicaseViral Replication
Ribavirin10-039RNA-dependent RNA polymerases (RdRps) RNA capping activity Viral mutation rates ImmunomodulationViral Transcription/Replication

JAK Immunomodulation

ProductCat. No.TargetAntiviral Activity
Ruxolitinib (free base)10-042JAK1/JAK2 ImmunomodulationViral Replication
Ruxolitinib . phosphate salt10-043JAK1/JAK2 ImmunomodulationViral Replication
Tofacitinib10-046JAK1/JAK2 ImmunomodulationViral Replication
Tofacitinib . citrate10-047JAK1/JAK2 ImmunomodulationViral Replication

Other Chemicals

ProductCat. No.TargetAntiviral Activity
Imatinib . mesylate10-028Virion fusion with endosomal membraneViral Replication
Nelfinavir . mesylate10-032Post-entry inhibitorViral Replication
Nitazoxanide10-035Viral hemagglutinin Viral IE2Viral Maturation/Transcription/Replication
Oseltamivir . phosphate10-036Viral neuraminidase Release of viral particlesViral Replication
Lopinavir10-029Coronavirus endopeptidase C30 (CEP_C30)Viral Maturation/Replication
Ritonavir10-040Coronavirus endopeptidase C30 (CEP_C30)Viral Maturation/Replication