Introduction Download the white paper! Exploring the Roles of RIPKs in Immune Responses Inflammation and Cell Death: Recent Findings – The RIPK family comprises seven proteins (RIP1, RIP3, RIP4, RIP5, RIP6, RIP7, and DIK) that are involved in cytokine stimulation,...
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Download the white paper! ProSci brand brings more than 25 years of antibody expertise in developing high quality single domain Variable Heavy domain of Heavy chain (VHH), recombinant, monoclonal, and polyclonal antibodies. In addition, our custom antibody services provide the...
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What is an inflammasome? An inflammasome is a formation of danger-sensing proteins when a cell becomes infected or damaged and is typically there to regulate the activation of caspase-1 and activate inflammation when host proteins create infectious microbes and molecules....
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Immune Evasion of Cancer – Mistakes happen. It’s a fact of life, and when mistakes occur during cell replication, the body has mechanisms to catch these errors and destroy the defective cells. However, when this system fails, it can lead...
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SARS-CoV-2 Open Reading Frames (ORFs) – The SARS-CoV-2 genome is ~29 kb divided into 10 open reading frames (ORFs). Each of these ORFs (except seemingly ORF10) is translated in 29 different proteins. ORF1 is formed by two overlapping ORFs, ORF1a...
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Immune Evasion of SARS-CoV-2 – Viruses use a variety of processes to evade the immune system and buy time to replicate. Some of these processes include inhibition of the humoral response, interfering, inhibiting, and modulating interferons, cytokines, chemokines, and apoptosis,...
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Cytokine Storm and COVID-19 What is Cytokine Storm? – Garnering mass attention due to the COVID-19 pandemic caused by the SARS-CoV-2 virus, the “cytokine storm” has been observed for decades. Cytokine storm refers to the overproduction of cytokines by the...
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The Importance of Quality Immuno-oncology Antibody Reagents In Studying Immune Checkpoint Inhibitors These days, it’s tough to mention cancer without also mentioning the novel class of cancer-fighting immuno-oncology therapeutics called immune checkpoint inhibitors. These transformative drugs have extended the life...
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Many scientists expressing interest in single domain antibodies have been curious about the best ways to detect single domain antibodies with in vitro assays. When detecting typical IgG antibodies, secondary antibodies with conjugated enzymes or fluorophores are used for detection...
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Why Are Antibodies Produced in the Body? – Antibody Production in Human Body serves three primary roles in the immune system: neutralization, opsonization, and complement protein activation. These essential functions protect the body from harmful pathogens, ensuring the immune system...
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