January 2017: The Antibody Update – Mitigating the Reproducibility Crisis in Cancer Drug Research Reproducibility has been highlighted as one of the main problems when validating cancer research. Scientists with the The Reproducibility Project have opted to begin pragmatically reviewing...
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T-cell Activation: The Purpose of CD28, CTLA-4, and CD80/CD86 – A Guide to CD28, CTLA-4, and CD80/CD86 Interaction and Signaling Immune checkpoint receptors like CD28 and CTLA-4 have been of great interest in the research of cancer immunotherapy. These receptors...
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Merck’s Ebola Vaccine is 100% Effective December 2016: The Antibody Update – An extremely effective Ebola virus vaccine created by Merck was recently tested in Guinea with 100% effectiveness. Though the vaccine is late for the worst part of the...
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in China Perform First Injection of CRISPR Modified Cells into a Person Use of CRISPR-Cas9 in human cells for treatment of disease has been a controversial topic amongst scientists since the discovery of the powerful gene editing tool. In this...
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Bacterial vs. Mammalian Expression Systems – Expressing recombinant antibodies can be done in all kinds of systems. Many different cell lines can be used for expressing antibodies, including mammalian cells like HEK293 or CHO, or even yeast, plant or insect...
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October 2016: The Antibody Update – The Nobel Prize in Medicine was Awarded to Yoshinori Ohsumi for His Work on Autophagy Autophagy is the cellular process that regulates a cells ability to degrade parts of itself that must be replaced....
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Antibody Basics: Recombinant Antibodies Antibody development works much like any engineering feat; you get out what you put in. With the shotgun approach to developing polyclonal antibodies, hitting the target usually isn’t too much of a problem, but the immune...
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September 2016: The Antibody Update – A Monoclonal Antibody Against Amyloid-Beta Plaques Strengthens the Amyloid Hypothesis Aducanumab is a novel monoclonal antibody that has been designed to target the amyloid-beta plaques closely associated with Alzheimer’s disease. Specifically, Aducanumab is a...
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Antibody Basics: Isotypes – Antibodies come in several shapes and sizes, leading to a variance in properties and purposes. Below is a broad outline of each of the major isotypes of antibodies and how they are used. Some isotypes can...
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August 2016: The Antibody Update – T-cells Run Out of Energy When Fighting in Tumors T-cells were shown to have decreased levels of oxidative metabolism and lower numbers of mitochondria after entering a tumor’s microenvironment. It was shown that T-cells...
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