In this blog, ProSci will take you through the advantages of single domain antibodies—also known as Nanobodies™, VHH antibodies, and camelid antibodies—and the process ProSci uses to develop high-performing antibodies. Single Domain Antibodies (sdAbs) from the camelid family are exciting...
Share this post:
New SARS-CoV-2 Recombinant Virus Lineages – Three SARS-CoV-2 recombinant lineages have been designated by Pangolin as of March 2022, two a combination of Delta and BA.1 (designated XD and XF), and the third a combination of Omicron BA.1 and Omicron...
Share this post:
There are many ways single domain antibodies (sdAbs) — also known as Nanobodies™, VHH antibodies, and camelid antibodies are superior to conventional antibodies. Read on to find out how these unique antibodies can enhance your research. The Advantages of Single...
Share this post:
SARS-CoV-2 protease Mpro (NSP5), a key to COVID-19 therapy? – Pfizer announced promising clinical trials for their drug Paxlovid (Owen et al., 2021), an inhibitor of the main SARS-CoV-2 protease, Mpro (3CLpro, NSP5). In addition to being the main SARS-CoV-2...
Share this post:
ProSci applauds the work described in two recent publications regarding the synthesis, production, and utility of SARS-CoV-2 virus-like particles (VLPs). SARS-CoV-2 Virus-like Particles (VLPs) – Naskalska et al. (2021) (DOI: 10.3389/fmicb.2021.732998) created recombinant His-tagged forms of SARS-CoV-2 structural proteins that...
Share this post:
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children Loske et al. (2021) https://www.nature.com/articles/s41587-021-01037-9 The recent study by Loske et al (2021) investigated why children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
Share this post:
Immune Evasion of Cancer – Mistakes happen. It’s a fact of life, and when mistakes occur during cell replication, the body has mechanisms to catch these errors and destroy the defective cells. However, when this system fails, it can lead...
Share this post:
Immune Evasion of SARS-CoV-2 – Viruses use a variety of processes to evade the immune system and buy time to replicate. Some of these processes include inhibition of the humoral response, interfering, inhibiting, and modulating interferons, cytokines, chemokines, and apoptosis,...
Share this post:
SARS-CoV-2 Open Reading Frames (ORFs) – The SARS-CoV-2 genome is ~29 kb divided into 10 open reading frames (ORFs). Each of these ORFs (except seemingly ORF10) is translated in 29 different proteins. ORF1 is formed by two overlapping ORFs, ORF1a...
Share this post:
[siteorigin_widget class=”SiteOrigin_Widget_Image_Widget”][/siteorigin_widget] Antibody Development vs Antibody Production. The terms development and production are often used interchangeably in the antibody industry which has caused some degree of confusion. The mix-up is understandable, since one procedure is just an extension of the...
Share this post:
