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Inflammasome Research Reagents

Explore the full catalog of inflammasome research reagents from ProSci!

Discovered by Dr. Jürg Tschopp at the University of Lausanne in 2002, inflammasomes were recognized to play a role in diseases such as Type 2 Diabetes and Gout (1, 2). Inflammasomes have since been shown to play an important part in the Innate Immune System, working as a first-line defense against pathogens and host “danger” signals.

Inflammasomes are protein complexes present in the cytosol that activate Caspase 1 (CASP1) leading to the induction of pro-inflammatory cytokines and pyroptosis (cell death) (3). Assembly of Inflammasome is activated by pattern recognition receptors (PRRs) responding to pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) of the host cells (4).

  • Canonical Inflammasomes are typically comprised of a sensor, an adaptor protein (ASC), and pro-caspase-1. Sensors include NLRP1, NLRP3, NAIP/NLRC4, NLRP6, NLRP7, AIM2, IFI16, and Pyrin.
  • The non-canonical Inflammasome pathway involves human caspases CASP4, CASP5, and their Murine orthologs CASP11 or CASP8 (5, 6).

Inflammasome Reagents

To further support inflammasome research, ProSci is pleased to offer antibodies against each component of inflammasome protein complexes as well as those proteins involved in the Pyroptosis Response.

NAIP

ProductCat. No.ApplicationClonalitySpecies
NAIP Antibody3315ELISA, ICC, IF, WBPolyclonalRabbit
NAIP1/2/5 Antibody [Naipa-1]36-158WBMonoclonalMouse

NLRC4

ProductCat. No.ApplicationClonalitySpecies
Ipaf Antibody3107ELISA, ICC, IF, WBPolyclonalRabbit
CARD12 Antibody30-999ELISA, IHC, WBPolyclonalRabbit
CARD12 Antibody14-800IF, IHC, WBPolyclonalRabbit

NLRP1

ProductCat. No.ApplicationClonalitySpecies
NALP1 Antibody3037ELISA, ICC, IF, WBPolyclonalRabbit
NLRP1/NALP1 Antibody36-322WBPolyclonalRabbit
NALP1 Antibody [Nalpy1-4]
XA-1024ICC, IHC, IP, WBMonoclonalMouse

NLRP3

ProductCat. No.ApplicationClonalitySpecies
NALP3 Antibody5447ELISA, ICC, IF, WBPolyclonalRabbit
NLRP3 Antibody42-536IHCPolyclonalGoat
NLRP3 Antibody [Nalpy3-b]70-291IHC, IP, WBMonoclonalMouse
NNALP3 Antibody [Nalpy3-b]
XA-1033IP, WBMonoclonalMouse
NLRP3/NALP3 Antibody [Cryo-1]36-099WBMonoclonalMouse
Cryopyrin Antibody45-435ELISA, Flow, IFPolyclonalGoat
Cryopyrin Antibody45-436ELISA, IHCPolyclonalGoat

NLRP6

ProductCat. No.ApplicationClonalitySpecies
NALP6 Antibody5961ELISA, IF, WBPolyclonalRabbit
Mouse Nlrp6 Antibody58-631WBPolyclonalRabbit
NLRP6/NALP6 Antibody [Clint-1]36-159IHC, WBMonoclonalMouse

NLRP7

ProductCat. No.ApplicationClonalitySpecies
NALP7 Antibody5963ELISA, IF, IHC-P, WBPolyclonalRabbit

AIM2

ProductCat. No.ApplicationClonalitySpecies
AIM2 Antibody26-540ELISA, WBPolyclonalRabbit
AIM2 Antibody42-531ELISA, IHC, WBPolyclonalGoat
AIM2 Antibody43-432ELISA, WBPolyclonalGoat
Aim2 Antibody43-354ELISAPolyclonalGoat

IFI16

ProductCat. No.ApplicationClonalitySpecies
IFI16 (CT) Antibody
9641ELISA, IHC, IF, WBPolyclonalRabbit
IFI16 Antibody
15-315IHC, WBPolyclonalRabbit

Pyrin

ProductCat. No.ApplicationClonalitySpecies
MEFV Antibody27-480ELISA, WBPolyclonalRabbit
MEFV Antibody45-880ELISA, Flow, IFPolyclonalGoat
AIM2 Antibody36-331IP, WBPolyclonalRabbit
MEFV Antibody60-653WBPolyclonalRabbit

ASC

ProductCat. No.ApplicationClonalitySpecies
ASC Antibody2287ELISA, ICC, IHC-P, WBPolyclonalRabbit
PYCARD Antibody28-647ELISA, WBPolyclonalRabbit
PYCARD Antibody45-129ELISA, IHC, WBPolyclonalGoat
ASC / TMS1 Antibody16-706IF, IHC, IP, WBPolyclonalRabbit
Pycard Antibody43-303ELISA, WBPolyclonalGoat
Pycard Antibody43-304ELISAPolyclonalGoat

CASP1

ProductCat. No.ApplicationClonalitySpecies
Caspase-1 Antibody3459ELISA, IHC-P, WBPolyclonalRabbit
Caspase-1 Antibody3463ELISA, IF, IHC-P, WBPolyclonalRabbit
CASP1 / Caspase 1 Antibody70-964IHC, IP, WBPolyclonalRabbit
Caspase 1 Antibody13-340IF, IHC, IP, WBPolyclonalRabbit

CASP4

ProductCat. No.ApplicationClonalitySpecies
Caspase-4 Antibody3451ELISA, IF, IHC-P, WBPolyclonalRabbit
Caspase-4 Antibody3453ELISA, IF, IHC-P, WBPolyclonalRabbit
Caspase-13 Antibody2245ELISA, IHC-P, WBPolyclonalRabbit
CASP4 Antibody45-363ELISA, WBPolyclonalGoat

CASP5

ProductCat. No.ApplicationClonalitySpecies
Caspase-5 Antibody3455ELISA, WBPolyclonalRabbit
Caspase-5 Antibody3457ELISA, ICC, IF, WBPolyclonalRabbit

CASP11

ProductCat. No.ApplicationClonalitySpecies
Caspase-11 Antibody [8A5]36-182ELISA, Flow, IP, WBMonoclonalRat
Caspase-11 Antibody [4E11]36-183ELISA, Flow, IP, WBMonoclonalRat
CASP11 Antibody22-267IHC, WBPolyclonalRabbit

CASP8

ProductCat. No.ApplicationClonalitySpecies
Caspase-8 Antibody3473ELISA, ICC, IF, IHC-P, WBPolyclonalRabbit
Caspase-8 Antibody3475ELISA, WBPolyclonalRabbit
Caspase8 Antibody79-642WBPolyclonalRabbit
Caspase-8 Antibody [C15]36-164ICC, IP, WBMonoclonalMouse
Caspase 8 Antibody13-984IF, IHC, WBPolyclonalRabbit
Caspase-8 Antibody [1G12]36-180WBMonoclonalRat
Caspase-8 Antibody [3B10]36-181ELISA, Flow, ICC, IHC, WBMonoclonalRat
Caspase-8 Antibody [SD125a]99-811Electron Microscopy, ELISA, Flow, ICC, IHC-Fr, IHC-P, IP, WBMonoclonalRat

References

  1. Martinon, F., Burns, K., & Tschopp, J. (2002, August 1). The Inflammasome. /www.cell.com. Retrieved August 23, 2022, from https://doi.org/10.1016%2FS1097-2765%2802%2900599-3
  2. Dagenais, M., Skeldon, A., & Saleh, M. (2011, November 11). The inflammasome: In memory of dr. Jurg Tschopp. Nature News. Retrieved August 23, 2022, from https://www.nature.com/articles/cdd2011159
  3. Chavarría-Smith, J., & Vance, R. E. (2015, April 16). The NLRP1 inflammasomes – Chavarría‐Smith – Wiley Online Library. onlinelibrary.wiley.com. Retrieved August 23, 2022, from https://onlinelibrary.wiley.com/doi/10.1111/imr.12283
  4. Broz, P., & Dixit, V. M. (2016, June 13). Inflammasomes: Mechanism of assembly, regulation and signalling. Nature News. Retrieved August 23, 2022, from https://www.nature.com/articles/nri.2016.58
  5. Russo, A. J., Behl, B., Banerjee, I., & Rathinam, V. A. K. (2018, January 19). Emerging Insights into Noncanonical Inflammasome Recognition of Microbes. www.sciencedirect.com. Retrieved August 23, 2022, from https://doi.org/10.1016/j.jmb.2017.10.003
  6. Zheng, D., Liwinski, T., & Elinav, E. (2020, June 9). Inflammasome activation and regulation: Toward a better understanding of complex mechanisms. Nature News. Retrieved August 23, 2022, from https://www.nature.com/articles/s41421-020-0167-x

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Inflammasome research reagents from ProSci
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